Dr. Mathis is a Professor of Medicine at Harvard Medical School and a Senior Investigator at Joslin Diabetes Center, and an Associate Member at the Broad Institute. Her laboratory works in the fields of T-cell differentiation and autoimmunity, with a special emphasis on exploiting the most advanced transgenic and gene-targeting technologies to engineer new mouse models. Her studies on T cell differentiation focus on the selection of the T-cell repertoire, in particular the cellular and molecular mechanisms of positive and negative selection and lineage commitment. Her work on autoimmunity explores the immunological mechanisms of diabetes, rheumatoid arthritis and autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) using modern genetic and genomic approaches in both human patients and mouse models, and computational and bioinformatics strategies. Dr. Mathis is the co-head of the Section on Immunology and Immunogenetics at Joslin, and is the Director of the Juvenile Diabetes Research Foundation (JDRF) Center on Immunological Tolerance in Type 1 Diabetes at Harvard Medical School. Dr. Mathis is a member of the National Academy of Sciences, and is a recipient of numerous awards, including the Romancon Prize and the Foundation Athena Research Prize. Dr. Mathis received her doctoral Ph.D. from the University of Rochester in 1977.